Ezatiostat
作者：齐岳
发布时间：2023-09-06
09:00:56
点击数：
产品名称：Ezatiostat
产品描述：
| 产品描述 | Ezatiostat is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity. |
| 体内活性 | Ezatiostat was administered to 19 patients with non-deletion(5q) myelodysplastic syndrome (MDS) at one of two doses (2000 mg or 2500 mg/day) in combination with 10 mg of lenalidomide on days 1-21 of a 28-day cycle. One of 4 evaluable patients (25%) in the 2500/10 mg dose group experienced an erythroid hematologic improvement (HI-E) response by 2006 MDS International Working Group (IWG) criteria. Four of 10 evaluable patients (40%) in the 2000 mg/10 mg dose group experienced a HI-E response [1]. Systemic inhibition of GSTP1 with Ezatiostat (0-30 mg/kg, i.p.) dose-dependently reduced the reinforcing effects of alcohol as measured by operant self-administration, in the absence of motor effects [2]. |
| 别名 | TLK199, TER199(free base) |
| 分子量 | 529.65 |
| 分子式 | C27H35N3O6S |
| CAS No. | 168682-53-9 |
存储
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: Insoluble
DMSO: >50 mg/mL (94.4 mM)
Ethanol: 20 mg/mL (37.76)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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