FN-1501
作者：齐岳
发布时间：2023-08-23
09:20:17
点击数：
产品名称：FN-1501
产品描述：
| 产品描述 | FN-1501 is a potentFLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-1501 also has anticancer activity. |
| 靶点活性 | cdk2/cyclin A:2.47 nM, CDK6/cyclinD1:1.96 nM, Cdk4/cyclin D1:0.85 nM, FLT3:0.28 nM |
| 体外活性 | FN-1501 displays potent inhibitory activity against several tumor cells, such as MGC803, RS4;11, MCF-7, HCT-116, and NCI-H82 (GI50s of 0.37 ± 0.04, 0.05 ± 0.01, 2.84 ± 0.25, 0.09 ± 0.04, 0.11 ± 0.02 nM, respectively)[1]. |
| 体内活性 | FN-1501 shows potent antitumor activity and it also shows little cytotoxicity on normal lymphocyte cells (LD50: 185.67 mg/kg in ICR mice). FN-1501 (15. 30, or 40 mg/kg/d, i.v.) dose-dependently and obviously inhibits the growth of tumors in MV4-11-cell-inoculated-xenograft mice[1]. |
| 分子量 | 431.49 |
| 分子式 | C22H25N9O |
| CAS No. | 1429515-59-2 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 45 mg/mL (104.29 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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