Inecalcitol
作者：齐岳
发布时间：2023-08-30
09:02:46
点击数：
产品名称：Inecalcitol
产品描述：
| 产品描述 | Inecalcitol is the growth inhibitor of human breast cancer cells. Inecalcitol is a unique vitamin D3 analog with Kd of 0.53 nM. |
| 靶点活性 | vitamin D3:0.53 nM(Kd) |
| 体外活性 | A xenograft model of LNCaP cells was developed in immunodeficient mice treated with inecalcitol. The tumors of the diluent-treated control mice increased in size but those in the inecalcitol treatment group did not grow[1]. |
| 体内活性 | Inecalcitol maximal tolerated dose (MTD) by intraperitoneal (i.p.) administration was 30 μg/mouse (1,300 μg/kg) three times per week, while we previously found that the MTD of 1,25(OH)(2) D(3) is 0.0625 μg/mouse; therefore, inecalcitol is 480 times less hypercalcemic than 1,25OH2 D3[1]. Inecalcitol inhibits androgen-responsive prostate cancer growth in vivo. |
| 别名 | TX-522, TX522, TX 522, 伊奈骨化醇 |
| 分子量 | 400.59 |
| 分子式 | C26H40O3 |
| CAS No. | 163217-09-2 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 55 mg/ml (137.3 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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