5Z-7-Oxozeaenol
作者：齐岳
发布时间：2023-08-23
09:15:52
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产品名称：5Z-7-Oxozeaenol
产品描述：
| 结构类型 | 天然产物 > 其他 |
| 产品描述 | 5Z-7-Oxozeaenol is a potent, irreversible and selective inhibitor of transforming growth factor (TGF)-β-activated kinase 1 with IC50 of 8.1 nM for TAK1 and low activity against MEK1 with IC50 of 411 nM, it is also an inhibitor of VEGF-R2 with IC50 of 52 nM. |
| 靶点活性 | FLT3:170 nM, VEGFR-2:52 nM, PDGFR-β:340 nM, VEGFR-3:110 nM, MEK1:411 nM, TAK1:8.1 nM, B-RAF VE:6300 nM, Src:6600 nM |
| 体外活性 | 5Z-7-Oxozeaenol is a natural anti-protozoan compound from the fungal origin with inhibitory activity against VEGF-R3, FLT3, PDGFR-β, B-RAF VE, and SRC with IC50s of 110, 170, 340, 6300, and 6600 nM, respectively[1]. 5Z-7-Oxozaeenol inhibited PMA-induced AP-1 activity to almost basal levels in KT cells but had no effect on IL-1-induced NF-kB activity in KK cells[2]. 5Z-7-Oxozaeenol inhibits the JNK/p38 pathway, but it is not a direct inhibitor and is signal-specific. 5Z-7-Oxozaeenol prevents inflammation by inhibiting the catalytic activity of the TAK1 MAPK kinase[3]. |
| 别名 | LL-Z 1640-2, L783279, FR148083 |
| 分子量 | 362.37 |
| 分子式 | C19H22O7 |
| CAS No. | 253863-19-3 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 40 mg/mL (110.38 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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