CA-4948
作者：齐岳
发布时间：2023-08-22
09:28:13
点击数：
产品名称：CA-4948
产品描述：
| 产品描述 | Emavusertib is a potent IRAK4/FLT3 inhibtor. CA-4948 with anti-tumor activity. |
| 体外活性 | CA-4948, demonstrated good cellular activity in ABC DLBCL and AML cell lines.?Inhibition of TLR signaling leading to decreased IL-6 levels was also observed in whole blood assays.?CA-4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation.?CA-4948 was well tolerated in toxicity studies in both mouse and dog at efficacious exposure.?The overall profile of CA-4948 prompted us to select it as a clinical candidate for evaluation in patients with relapsed or refractory hematologic malignancies including non-Hodgkin lymphoma and acute myeloid leukemia[2]. |
| 别名 | Emavusertib |
| 分子量 | 491.508 |
| 分子式 | C24H25N7O5 |
| CAS No. | 1801344-14-8 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: < 0.1 mg/mL (insoluble)
DMSO: 27.78 mg/mL (56.52 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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