δ-secretase inhibitor 11
作者：齐岳
发布时间：2023-08-29
13:40:47
点击数：
产品名称：δ-secretase inhibitor 11
产品描述：
| 产品描述 | δ-secretase inhibitor 11 isan inhibitor ofδ-secretase and can be used as a lead compound for translational development of AD treatment. |
| 体外活性 | The inhibitory effect of δ-secretase inhibitor 11 on AEP activity in vitro was tested and the dose-response relationship revealed that the δ-secretase inhibitor 11 had an IC50 value of 0.15 ± 0.09 μM [1]. |
| 体内活性 | It was found that oral administration of δ-secretase inhibitor 11(10 mg/kg) significantly suppressed brain AEP activity compared to the vehicle treatment. The concentrations of Aβ1–40 and Aβ1–42 in brain lysates of SAMP8 mice were significantly reduced due to AEP inhibition by δ-secretase inhibitor 11. [1] |
| 分子量 | 220.232 |
| 分子式 | C10H12N4O2 |
| CAS No. | 842964-18-5 |
存储
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 2.2 mg/mL (10 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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