Paederosidic acid
作者：齐岳
发布时间：2023-08-30
09:00:44
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产品名称：Paederosidic acid
产品描述：
| 植物来源 | 天然产物 > 茜草科 > 鸡矢藤属 |
| 结构类型 | 天然产物 > 萜类 |
| 产品描述 | Paederosidic acid has significant anti-tumor, anticonvulsant and sedative effects. Paederosidic acid increases brain gamma-aminobutyric acid and decreases glutamic acid in the brain, and it up-regulates expressions of GAD 65, may be a promising future therapeutic agent for treatment of epilepsy. |
| 体外活性 | Paederosidic acid(PA) showed significant anti-tumor activity on lung cancer in vitro; the mechanisms were involved in inducing mitochondria-mediated apoptosis via up-regulation of caspase-3, caspase-8, caspase-9, Bid, Bax, down-regulation of Bcl-2 and stimulating the release of Cyto-C from mitochondria.JNK phosphorylation levels significantly increased concomitantly with decrease in Akt phosphorylation after treatment with PA in A549 cells. However, JNK siRNA-transfected cells diminished PA-induced caspase-3, 8 and 9, Bid and Bax activaton while enhanced the Bcl-2 activation. PA-induced JNK activation played an important functional role in apoptosis[1]. |
| 体内活性 | Anticonvulsant and sedative effects of paederosidic acid isolated from Paederia scandens (Lour.) Merrill. in mice and rats.Paederosidic acid (5, 10, 20, and 40 mg/kg, ip) had significant anticonvulsant and sedative effects. paederosidic acid increased brain gamma-aminobutyric acid and decreased glutamic acid in the brain, and it up-regulated expressions of GAD 65. Paederosidic acid may be a promising future therapeutic agent for treatment of epilepsy[2]. |
| 细胞实验 | The anti-proliferative effects of PA on A549 cells were evaluated by MTT method and the IC50 values were calculated. Furthermore, the PA-induced apoptosis in A549 cells was determined by fluorescence microscope via staining with DAPI and by flow cytometer via staining with FITC conjugated Annexin V/PI. The expression of apoptosis-related or signaling proteins was investigated by Western blotting[1] |
| 动物实验 | Anticonvulsant activities of paederosidic acid were evaluated by maximal electroshock and pentylenetetrazole-induced seizures in male mice. Then, pentobarbital sodium-induced sleeping time and locomotor activity tests in mice were used to evaluate the sedative effects of paederosidic acid. Finally, the mechanism of paederosidic acid was explored by evaluating the contents of Glu and GABA in the brain, and Western blot was used to measure GAD65 expression in the mouse brain[2]. |
| 别名 | 鸡屎藤苷酸, 异戊二酸 紫草酸 |
| 分子量 | 464.4 |
| 分子式 | C18H24O12S |
| CAS No. | 18842-98-3 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 55 mg/mL (118.42 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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