(±)-α-Bisabolol
作者：齐岳
发布时间：2023-08-30
09:00:21
点击数：
产品名称：(±)-α-Bisabolol
产品描述：
| 结构类型 | 天然产物 > 多糖和糖苷 |
| 产品描述 | (±)-α-Bisabololis a sesquiterpenol extracted from essential oils of chamomile, candida and other plants. It isa natural antiseptic with soothing, antiirritating, anti-inflammatory, antioxidant and anticancer activities. (±)-α-Bisabolol has anticancer effects on A549 NSCLC cells by inducing cell cycle arrest, mitochondrial death and inhibiting PI3K/Akt signaling (IC50 = 15 μM). (±)-α-Bisabolol can induce apoptosis of glioma cells. |
| 靶点活性 | PI3K/Akt:15 μM |
| 体外活性 | Under resting tonus, (–)-a-bisabolol (30–300 µmol/L) relaxed duodenal strips. Contracting endothelium-intact aortic rings and urinary bladder strips, and relaxing these tissues at higher concentrations (600–1000 µmol/L). In preparations precontracted either electromechanically (by 60 mmol/L K+) or pharmacomechanically (by phenylephrine or carbachol), (–)-a-bisabolol showed only relaxing properties. [1] |
| 体内活性 | (-)-α-Bisabolol (100-200 mg/kg; p.o.; one day before and 1 h after pMCAO; once daily for the following five days; mice) significantly reduces the infarcted area and neurological deficits caused by pMCAO. (−)-α-bisabolol can exert anti-inflammatory effects by reducing astrogliosis, MPO activity, and TNF-α and iNOS production.[1] (–)-a-bisabolol attenuated the increased responses of carbachol in tracheal rings of ovalbumin-sensitized rats challenged with ovalbumin, but was without effect in the decreased responsiveness of urinary bladder strips in mice treated with ifosfamide. (–)-a-bisabolol may be an inhibitor of voltage-dependent Ca2+ channels.[2] |
| 别名 | Bisabolol |
| 分子量 | 222.37 |
| 分子式 | C15H26O |
| CAS No. | 515-69-5 |
存储
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 90.0 mg/mL (404.7 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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