Evocarpine
作者：齐岳
发布时间：2023-08-30
09:02:48
点击数：
产品名称：Evocarpine
产品描述：
| 植物来源 | 天然产物 > 芸香科 > 吴茱萸属 |
| 结构类型 | 天然产物 > 生物碱 |
| 产品描述 | Evocarpine shows antimycobacterial, and vasorelaxant effects, it can inhibit Ca2+ influx through voltage-dependent calcium channels. |
| 体外活性 | The antimycobacterial and modulating activity of evodiamine (1), rutaecarpine (2) and Evocarpine (3) was tested on mycobacteria including three multidrug-resistant (MDR) clinical isolates of Mycobacterium tuberculosis. Antagonistic effects were concluded from fractional inhibitory concentration (FICI) values. Interaction energies of the compounds were calculated using GLUE docking module implemented in GRID. 1 and 2 exhibited weak inhibition of rapidly growing mycobacteria, however, 1 was active against Myco. tuberculosis H37Rv (MIC = 10 mg l(-1) ) while 2 was inactive. Both 1 and 2 showed a marked antagonistic effect on the susceptibility of different mycobacterial strains to 3 giving FICI values between 5 and 9. The interaction energies between compounds 1 and 2 with compound 3 suggested the possibility of complex formation in solution[1] |
| 分子量 | 339.51 |
| 分子式 | C23H33NO |
| CAS No. | 15266-38-3 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 50 mg/mL (147.27 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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