Friedelin
作者：齐岳
发布时间：2023-08-29
13:40:48
点击数：
产品名称：Friedelin
产品描述：
| 植物来源 | 天然产物 > 灯心草科 > 灯心草属 |
| 结构类型 | 天然产物 > 萜类 |
| 产品描述 | Friedelin possesses antioxidant, gastroprotective, anti-diarrhoeal, liver protective, anti-inflammatory, analgesic and antipyretic activities. |
| 靶点活性 | CYP2E1:22.54 μM (IC50), CYP3A4:Ki: 6.16 μM, CYP2E1:18.02 μM (IC50), CYP3A4:10.79 μM (IC50) |
| 体外活性 | In in vitro antioxidant study, the free radical scavenging effect of Friedelin on 2,2-diphenyl-picrylhydrazyl (DPPH), hydroxyl, nitric oxide and superoxide radicals were evaluated. Friedelin showed very good scavenging effect on DPPH (IC50 21.1 mM), hydroxyl (IC50 19.8 mM), nitric oxide (IC50 22.1 mM) and superoxide (IC50 21.9 mM) radicals. Friedelin also showed strong suppressive effect on lipid peroxidation. In in vivo antioxidant study, CCl4 induced oxidative stress on rats produced significant increase in serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and lactate dehydrogenase (LDH) levels along with reduction in liver superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH) and glutathione peroxidase (GPx) levels. Pre-treatment of rats with Friedelin at 40 mg/kg for 7 days restored these levels to normality and showed liver protection, comparable to the standard, silymarin (25 mg/kg)[1] |
| 别名 | 软木三萜酮, 无羁萜 |
| 分子量 | 426.72 |
| 分子式 | C30H50O |
| CAS No. | 559-74-0 |
存储
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: Insoluble
DMSO: Insoluble
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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