CNX-774
作者：齐岳
发布时间：2023-08-23
09:17:11
点击数：
产品名称：CNX-774
产品描述：
| 产品描述 | CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM). |
| 靶点活性 | BTK:<1 nM |
| 体内活性 | 在细胞试验中,CNX-774以BTK的ATP结合位点Cys-481残基为靶点从而抑制其活性（IC50：1-10 nM）。 |
| 激酶实验 | In vitro kinase assays: The p38α and p38β are assayed in 25 mM Tris-HCl, pH 7.5, containing 0.1 mM EGTA, with myelin basic protein (0.33 mg/mL) as substrate. Assays are performed either manually for 10 minutes at 30 °C in 50 μL incubations using [γ-33P]ATP, or with a Biomek 2000 Laboratory Automation Workstation in a 96-well format for 40 minutes at ambient temperature in 25 μL incubations using [γ-33P]ATP. The concentrations of ATP and magnesium acetate are 0.1 mM and 10 mM respectively. All assays are initiated with MgATP. Manual assays are terminated by spotting aliquots of incubation on to phosphocellulose paper, followed by immersion in 50 mM phosphoric acid. Robotic assays are terminated by the addition of 5 μL of 0.5 M phosphoric acid before spotting aliquots on to P30 filter mats. All papers are then washed four times in 50 mM phosphoric acid to remove ATP, once in acetone (manual incubations) or methanol (robotic incubations), and then dried and counted for radioactivity. |
| 别名 | CNX 774 |
| 分子量 | 499.506 |
| 分子式 | C26H22FN7O3 |
| CAS No. | 1202759-32-7 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Ethanol: 2 mg/mL (4.0 mM)
H2O: <1 mg/mL
DMSO: 93 mg/mL (186.2 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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