BTR-1
作者：齐岳
发布时间：2023-09-06
09:00:56
点击数：
产品名称：BTR-1
产品描述：
| 产品描述 | 5-Benzylidene-3-ethyl rhodanine(BTR-1) is an active anti-cancer agent. BTR-1 activates apoptosis and induces cell death. |
| 体外活性 | 5-isopropylidiene derivatives of 3-dimethyl-2-thio-hydantoin (ITH-1), 3-ethyl-2-thio-2,4-oxazolidinedione (ITO-1), and 5-Benzylidene-3-ethyl rhodanine(BTR-1), and have tested their chemotherapeutic properties. All three compounds induced cytotoxicity in a time- and concentration-dependent manner on leukemic cell line, CEM. Among the compounds tested, BTR-1 was 5- to 7-fold more potent than ITH-1 and ITO-1 when compared by trypan blue and MTT assays. IC(50) value of BTR-1 was estimated to be <10μM. Both cell cycle analysis and tritiated thymidine assays revealed that BTR-1 affects DNA replication by inducing a block at S phase. BTR-1 treatment led to increased level of ROS production and DNA strand breaks suggesting activation of apoptosis for induction of cell death. |
| 别名 | 5-Benzylidene-3-ethyl rhodanine |
| 分子量 | 249.35 |
| 分子式 | C12H11NOS2 |
| CAS No. | 18331-34-5 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 25 mg/mL (100.26 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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