SAR131675
作者：齐岳
发布时间：2023-08-23
09:38:02
点击数：
产品名称：SAR131675
产品描述：
| 产品描述 | SAR 131675 is a potent and selective VEGFR3 inhibitor with an IC50 of 23 nM. |
| 靶点活性 | VEGFR3:23 nM |
| 体外活性 | KU-0060648 exhibits differential effects on growth inhibition, but is not profoundly cytotoxic in a panel of human cancer cell lines. It inhibits DNA-PK and PI-3K with greater potency in MCF7 than SW620 cell using cell-based assays. Five-day exposure to 1 mM KU-0060648 inhibits cell proliferation by more than 95% in MCF7 cells but only by 55% in SW620 cells. In clonogenic survival assays, KU-0060648 increases the cytotoxicity of etoposide and doxorubicin across the panel of DNA-PKcs-proficient cells, but not in DNA-PKcs-deficient cells, confirming that enhanced cytotoxicity of the topoisomerase II poisons etoposide and doxorubicin is due to DNA-PK inhibition. [1] |
| 别名 | SAR 131675 |
| 分子量 | 358.4 |
| 分子式 | C18H22N4O4 |
| CAS No. | 1433953-83-3 |
存储
store at low temperture | Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Ethanol: <1 mg/mL
DMSO: 16.67 mg/mL (46.51 mM),ultrasonic and adjust pH to 2 with HCl
H2O: <1 mg/mL
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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