Tirbanibulin dihydrochloride
作者：齐岳
发布时间：2023-08-25
09:10:32
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产品名称：Tirbanibulin dihydrochloride
产品描述：
| 产品描述 | Tirbanibulin is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines). |
| 靶点活性 | Src HepG2:60 nM, Src PLC/PRF/5:13 nM, Src HuH7:(GI50)9 nM, Src Hep3B:26 nM |
| 体外活性 | Tirbanibulin (KX2-391) is found to inhibit certain leukemia cells that are resistant to current commercially available drugs, such as those derived from chronic leukemia cells with the T3151 mutation. KX2-391 displays steep dose-response curves against Huh7 (GI50=9 nM), PLC/PRF/5 (GI50=13 nM), Hep3B (GI50=26 nM), and HepG2 (GI50=60 nM), four hepatic cell cancer (HCC) cell lines[1]. Tirbanibulin is evaluated in engineered Src driven cell growth assays inNIH3T3/c-Src527F and SYF/c-Src527F cells and exhibits GI50 with 23 nM and 39 nM, respectively[2]. |
| 体内活性 | In pre-clinical animal models of cancer, Tirbanibulin (p.o.) is shown to inhibit primary tumor growth and to suppress metastasis[2]. |
| 别名 | KX-01 (dihydrochloride), KX2-391 (dihydrochloride) |
| 分子量 | 504.45 |
| 分子式 | C26H31Cl2N3O3 |
| CAS No. | 1038395-65-1 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 33.33 mg/mL (66.07 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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