AAL-993
作者：齐岳
发布时间：2023-08-25
09:00:29
点击数：
产品名称：AAL-993
产品描述：
| 产品描述 | AAL-993 is a potent VEGFR inhibitor with IC50s of 130 nM, 23 nM and 18 nM for VEGFR1, VEGFR2 and VEGFR3, respectively. AAL993 has a weak inhibitory effect on other tyrosine kinases. AAL993 also shows potent antiangiogenic and antitumor activities. |
| 靶点活性 | VEGFR1:130 nM, VEGFR3:18 nM, VEGFR2:23 nM |
| 体外活性 | AAL993 suppressed HIF-1α expression through the inhibition of ERK without affecting Akt phosphorylation[1]. |
| 体内活性 | AAL993 (24-100 mg/kg; p.o.) inhibited both the growth of the primary tumor as well as the formation of spontaneous peripheral metastases in B16 melanoma xenograft model[2]. AAL993 potently inhibited VEGF-induced angiogenesis with an ED50 value of 7 mg/kg in an implant model[2]. |
| 分子量 | 371.363 |
| 分子式 | C20H16F3N3O |
| CAS No. | 269390-77-4 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 55 mg/mL (148.1 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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