Roblitinib
作者：齐岳
发布时间：2023-08-28
09:00:56
点击数：
产品名称：Roblitinib
产品描述：
| 产品描述 | FGF401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. Upon administration, FGF401 binds to and inhibits the activity of FGFR4, which leads to an inhibition of tumor cell proliferation in FGFR4-overexpressing cells. FGFR4 is a receptor tyrosine kinase upregulated in certain tumor cells and involved in tumor cell proliferation, differentiation, angiogenesis, and survival. |
| 靶点活性 | FGFR4:1.1 nM |
| 体内活性 | FGF-401 is a FGFR4 inhibitor developed for the treatment of solid tumor. FGF-401 is a FGFR4 inhibitor in phase I/II Clinicalal studies for the treatment of positive FGFR4 and KLB expresion solid tumors and hepatocellular carcinoma |
| 别名 | FGF-401 |
| 分子量 | 506.567 |
| 分子式 | C25H30N8O4 |
| CAS No. | 1708971-55-4 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 10mM
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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