Batatasin III
作者：齐岳
发布时间：2023-08-24
09:17:22
点击数：
产品名称：Batatasin III
产品描述：
| 植物来源 | 天然产物 > 兰科 > 石斛属 |
| 结构类型 | 天然产物 > 其他 |
| 产品描述 | Batatasin III inhibits cancer migration and invasion by suppressing epithelial to mesenchymal transition and FAK-AKT signals and possesses anti-cancer activities. Batatasin III has a long-term inhibitory effect on whole-plant growth and shows germination |
| 体内活性 | Batatasin III may impose a lethal effect on the aquatic fauna in small streams. The maximum concentration of Batatasin III found was 1.06 mg l(-1). The proportion of dead yolk sac alevins increased significantly (P < 0.001) with increasing concentrations of Batatasin III and time of exposure. After 24 hr, EC50 was 10 mg l(-1). It was 2 mg l(-1) after 48 hr. The effect of phenol was negligible, indicating a specific phytotoxic effect of the bibenzyl structure of Batatasin III. The proportion of mobile D. magna became significantly smaller (P < 0.001) with increasing concentrations of Batatasin III, with decreasing pH, and with increasing exposure time. EC50 varied between 7 and 17 mg l(-1) at pH 5.5 and 7.0, respectively. After 24 hr EC50 decreased and was 2.5 at pH 5.5 and 12 mg l(-1) at pH 7.0. The levels of Batatasin III found in the field samples were below the lowest EC50 in acute toxicity tests[1]. Batatasin III significantly suppresses mesenchymal transition indicated by the decrease of N-cadherin and Vimentin and up-regulation of E-cadherin[1]. Batatasin III (25-100 μM; 48 h) exhibits anti-proliferative activity in H460 cells. Batatasin III at concentrations lower than 100 μM has no cytotoxic effects[2]. |
| 分子量 | 244.29 |
| 分子式 | C15H16O3 |
| CAS No. | 56684-87-8 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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