Y15
作者：齐岳
发布时间：2023-08-24
09:17:26
点击数：
产品名称：Y15
产品描述：
| 产品描述 | Y15 is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth. |
| 体外活性 | Y15 inhibited viability in ?thyroid cancer cell lines in a dose-dependent manner[1]. |
| 细胞实验 | Apoptosis assay was done with PE Annexin V Apoptosis Detection Kit (BD) to identify apoptotic nuclei.?One hundred millimeter plates were seeded with TPC1, K1, BCPAP and TT cells at a concentration of 1 × 10^6 cells in normal growth media.?After overnight incubation, plates were treated with one of several doses of Y15 or left untreated.?After another 24 h of incubation, cells were collected with trypsin, and following centrifugation, were washed with 1× PBS.?Again, cells were centrifuged, PBS was removed and cells were resuspended in binding buffer and filtered through BD mesh tubes.?Annexin V and 7-AAD were added to the solution, vortexed and incubated for 15 minutes in the dark.?Binding buffer was added and the cells were analyzed by flow cytometry within 1 hour. |
| 别名 | 1,2,4,5-苯四胺四盐酸盐, FAK inhibitor Y15, 1,2,4,5-Benzenetetramine tetrahydrochlor, FAK Inhibitor 14 |
| 分子量 | 284.01 |
| 分子式 | C6H14Cl4N4 |
| CAS No. | 4506-66-5 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
H2O: 59 mg/mL (207.74 mM),Need ultrasonic and warming
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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