Negletein
作者：齐岳
发布时间：2023-09-06
09:05:31
点击数：
产品名称：Negletein
产品描述：
| 植物来源 | 天然产物 > 唇形科 > 黄芩属 |
| 产品描述 | 1. Negletein has anti-inflammatory and immunomodulatory activities via inhibition of TNF-α, iNOS and IL-1β. 2. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. 3. Negletein shows a comparable redox-active potential, and it (50 μM, 4 h) can activate Nrf2. 4. Negletein shows significant antimicrobial activity. 5. Negletein has anti-hypoxia activity, it can significantly prolong the survival time of hypoxic mice.6. Negletein has anti- Alzheimer's disease activity, it inhibits the iron-dependent formation of ROS and also blocks the iron-induced oligomerization of amyloid beta 42 in vitro. 7. Negletein (IC50: 3.89 +/- 0.39 microM) exhibits potent inhibitory activity against nuclear factor of activated T cells (NFAT) transcription factor. |
| 靶点活性 | IL-1β:10.8 nM (IC50), TNF-α:16.4 nM (IC50) |
| 别名 | 7-O-Methylbaicalein, 黄芩素-7-甲醚, Baicalein-7-methylether |
| 分子量 | 284.26 |
| 分子式 | C16H12O5 |
| CAS No. | 29550-13-8 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
DMSO: 50 mg/mL (175.9 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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