Propylparaben
作者：齐岳
发布时间：2023-09-05
08:53:55
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产品名称：Propylparaben
产品描述：
| 结构类型 | 天然产物 > 其他 |
| 产品描述 | Propylparaben is an antimicrobial agent, preservative, flavouring agent |
| 体外活性 | Propylparaben(PPB) suppressed the epileptiform activity in registered neurons.?This effect disappeared when PPB was removed from the solution of incubation.?PPB exerts an antiepileptic effect on CA1 pyramidal neurons in vitro.?Therefore, PPB may represent an effective antiepileptic compound[1]. propylparaben disrupts antral follicle growth and steroidogenic function by altering the cell-cycle, apoptosis, and steroidogenesis pathways[1]. |
| 细胞实验 | Experimental conditions were as follows: a) basal recordings during which artificial cerebrospinal fluid (ACSF) (in mM: NaCl,125; KCl, 3; Na2HPO4, 1.25; NaHCO3, 25; MgCl2, 2; CaCl2, 2-D-(+)-glucose, 10; gassed with a mixture of 95% O2–5% CO2) was perfused; b) ACSF plus Propylparaben(PPB) (500 μM); c) 4-AP (100 μM) in Mg2+free-ACSF; d) 4-AP in Mg2+free-ACSF plus vehicle (dimethyl sulfoxide, DMSO at 0.04%); e) 4-AP in Mg2+free-ACSF plus drugs (phenytoin (PHT), 200 μM; PPB, 200 and 7500 μM). Each experimental condition lasted for 10 min. The onset of 4-AP-induced epileptiform activity was considered when bursts of 5 of more consecutive action potentials (APs) were present. The number of APs and excitatory postsynaptic potentials (EPSPs) greater than 1 mV and less than 10 mV of amplitude were quantified during periods of 5 min for each experimental condition[2] |
| 别名 | 羟苯丙酯, Propyl parahydroxybenzoate, Propyl 4-hydroxybenzoate, 尼泊金丙酯 |
| 分子量 | 180.2 |
| 分子式 | C10H12O3 |
| CAS No. | 94-13-3 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 125 mg/mL (693.67 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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