Hexamethonium Bromide
作者：齐岳
发布时间：2023-09-05
08:51:46
点击数：
产品名称：Hexamethonium Bromide
产品描述：
| 产品描述 | Hexamethonium Bromide, a specific antagonist of neuronal-type nicotinic AChR in ganglia, is poorly absorbed from the gastrointestinal tract and does not cross the blood-brain barrier. |
| 体外活性 | Hexamethonium Bromide is effective against Ach and carbachol (CCh) on the amplitude of endplate responses of rat omohyoid muscle with EC50 of 300 μM and 100 μM, respectively. Hexamethonium Bromide (50-200 μM) causes an increase in the amplitude of nerve-evoked endplate currents (e.p.cs) recorded in the presence of 0.6 μM tubocurarine. Hexamethonium Bromide is also a weak inhibitor of acetylcholinesterase activity in rat muscle homogenates with EC50 of 1.5 mM. [1] Hexamethonium Bromide (200 μM) decreases the time constant of decay of both endplate currents (e.p.cs) (by ~25%) and miniature endplate currents (m.e.p.cs) (by ~20%) in the rat hemi-diaphragm muscle. At low frequencies of stimulation (0.5-2 Hz), Hexamethonium Bromide (200 μM) increases e.p.c. quantal content by 30-40%. [2] |
| 别名 | Hexamethonium Dibromide, Simpatoblock, Gangliostat, 溴化六甲铵, 六甲溴铵 |
| 分子量 | 362.19 |
| 分子式 | C12H30Br2N2 |
| CAS No. | 55-97-0 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 18.1 mg/mL (50 mM)
H2O: 36.2 mg/mL (100 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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