Dapivirine
作者：齐岳
发布时间：2023-08-30
09:02:49
点击数：
产品名称：Dapivirine
产品描述：
| 产品描述 | Dapivirine is a diarylpyrimidine non-nucleoside reverse transcriptase inhibitor. |
| 靶点活性 | HIV reverse transcriptase:24 nM |
| 体内活性 | Dapivirine-containing gel at vaginal level inhibits cell-associated HIV infection in mice. [3] More placebo (7 of 12) than Dapivirine (3 of 24) gel users has positive vaginal swab results, with white blood cells being the most common finding. Dapivirine (0.05%) results in Cmax of 715 pg/mL, AUC of 15 ng×h/mL and T1/2 of 89.87 hours in plasma after 14 days post-dose. Mean Dapivirine (0.05%) concentrations in vaginal fluids collected at the introitus, mid vagina, and cervix are in the range of 62-265 μg/g on day 1. [4] |
| 别名 | TMC120, 达匹维林, R147681 |
| 分子量 | 329.4 |
| 分子式 | C20H19N5 |
| CAS No. | 244767-67-7 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Ethanol: <1 mg/mL
DMSO: 32 mg/mL (97.1 mM)
H2O: <1 mg/mL
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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