δ-Tocotrienol
作者：齐岳
发布时间：2023-08-25
09:00:25
点击数：
产品名称：δ-Tocotrienol
产品描述：
| 植物来源 | 天然产物 > 棕榈科 > 棕榈属 |
| 结构类型 | 天然产物 > 其他 |
| 产品描述 | δ-Tocotrienol is a potential angiogenic inhibitor. δ-Tocotrienol is also a nontoxic activator of mir-34a which can inhibit nonsmall cell lung cancer cells (NSCLC) cell proliferation, induce apoptosis and inhibit invasion, and thus offering a potential starting point for the design of novel anticancer agents. |
| 体外活性 | δ-Tocotrienol induced apoptosis and cell cycle arrest at G0/G1 and M phases in nasopharyngeal carcinoma cells. After CNE1 cells were treated with δ-Tocotrienol, 169 genes were up-regulated and 167 down-regulated. ERK1/2 was shown to play a vital role in cell cycle arrest by gene chips. δ-Tocotrienol induces cell cycle arrest in CNE1 cells via the p16/CDK4/cyclin D1 signaling pathway. CNE1 apoptosis was related to dysregulated expression of Bax-2 and Bcl-2. Furthermore, caspase-3, -8, -9 up-regulation was related to the apoptotic effect of δ-Tocotrienol[1]. |
| 别名 | Delta-Tocotrienol, δ-生育三烯酚 |
| 分子量 | 396.61 |
| 分子式 | C27H40O2 |
| CAS No. | 25612-59-3 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 100 mg/mL (252.14 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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