PD-118057
作者：齐岳
发布时间：2023-08-25
08:58:42
点击数：
产品名称：PD-118057
产品描述：
| 产品描述 | PD-118057 is a potent ether associated (hERG) potassium channel activator that shows no activity against hERG. PD-118057 inhibits the excitability of the membrane by activating the hERG channel. PD-118057 is a potential compound for the treatment of delayed repolarization in inherited or acquired long QT syndrome and congestive heart failure. |
| 体外活性 | PD-118057 (3 μM and 10 μM) specifically increases hERG current and inhibits action potential duration in guinea pig ventricular muscle in acute isolation of guinea pig cardiomyocytes.[1][2]PD-118057 (10 μM) counteracts the current inhibition triggered by Dof and Mox while preserving the unaltered "hump" shape of the IKr current and exhibiting only a marginal increase in the maximum value of the suppressed current.[2] |
| 分子量 | 386.27 |
| 分子式 | C21H17Cl2NO2 |
| CAS No. | 313674-97-4 |
存储
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 90.0 mg/mL (233.0 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
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