JI6
作者：齐岳
发布时间：2023-08-22
09:22:15
点击数：
产品名称：JI6
产品描述：
| 产品描述 | JI6 is a potent, selective and orally active FLT3 inhibitor. JI6 exhibits IC50s of ∼40, 8, and 4 nM for FLT3-WT, FLT3-D835Y, and FLT3-D835H, respectively. JI6 also inhibits c-Kit and JAK3, with IC50s of ∼500 and ∼250 nM, respectively. JI6 has research value in acute myeloid leukemia. |
| 体外活性 | JI6 (3-1000 nM; 1-4 days) inhibits MV4-11 cell viability in a dose-dependent manner with IC50 of ∼25 nM. JI6 (1-2000 nM; 48 h) potently inhibits the viability of HCD-57 cells expressing FLT3-ITD, FLT3-D835Y and FLT3-D835H with IC50 of ∼40 nM. JI6 has no effect on the parent HCD-57 or JAK2V617F expressing cells. JI6 (100-500 nM; 24 h) induce apoptosis and cell cycle arrest in HCD-57 cells expressing FLT3-ITD and FLT3-D835Y. JI6 (50-500 nM; 3 h) inhibits phosphorylation of FLT3, ERK and Akt in HCD-57 cells expressing FLT3-ITD and FLT3-D835Y[1]. |
| 体内活性 | JI6 (15 mg/kg; i.p. daily for 3 weeks) inhibits the proliferation of HCD-57 expressing FLT3-D835Y in SCID mouse and prolong the survival. JI6 (25 mg/kg; p.o. daily for 3 weeks) inhibits myeloproliferative phenotype in FLT3-ITD knock-in mice. JI6 (100 mg/kg; a single i.p.) significantly inhibits FLT3 phosphorylation and downstream signal transduction in mice expressing FLT3-D835Y[1]. |
| 别名 | JAK3 Inhibitor VI |
| 分子量 | 383.42 |
| 分子式 | C19H17N3O4S |
| CAS No. | 856436-16-3 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 4.5 mg/mL (11.7 mM),Need ultrasonic
( < 1 mg/mL refers to the product slightly soluble or insoluble )
联系我们：
邮箱：2519696869@qq.com
QQ: 2519696869
电话：18066853083
微信：18066853083
公司介绍：
西安齐岳生物科技有限公司是集化学科研和定制与一体的高科技化学公司。业务范围包括化学试剂和产品的研发、生产、销售等。涉及产品为通用试剂的分销、非通用试剂的定制与研发，涵盖生物科技、化学品、中间体和化工材料等领域。
主营产品：COF、MOF单体系列：三蝶烯衍生物、金刚烷衍生物、四苯甲烷衍生物、peg、上转换、石墨烯、光电材料、点击化学、凝集素、载玻片、蛋白质交联剂、脂质体、蛋白、多肽、氨基酸、糖化学等。
