Swainsonine
作者：齐岳
发布时间：2023-08-30
09:00:18
点击数：
产品名称：Swainsonine
产品描述：
| 结构类型 | 天然产物 > 其他 天然产物 > 生物碱 |
| 产品描述 | Swainsonine is an alkaloid isolated from Astragalus membranaceus and is a potent and reversible inhibitor of alpha-mannosidase. swainsonine has antitumour activity and induces apoptosis and cell cycle arrest in the G2/M phase. |
| 靶点活性 | lysosomal α-mannosidase:0.2 μM, Golgi α-mannosidase II:0.2 μM |
| 体外活性 | Swainsonine (0-40 μM ;12 h) showed anti-proliferative activity in U251 and LN444 cells.[2] Swainsonine (30 μM ;12 h) induced apoptosis and cell cycle arrest in G2/M phase and decreased the expression of CyclinD1 and CDK4 protein levels and increased the expression of p16 protein level.[2] Swainsonine (30 μM ;12 h) reduces glioma cell migration and invasion.[2] |
| 体内活性 | Swainsonine (1 mg/kg ;intraperitoneal injection ;twice daily for 10 days) and cisplatin increased the antitumor efficacy in mice.[3] |
| 别名 | Tridolgosir |
| 分子量 | 173.21 |
| 分子式 | C8H15NO3 |
| CAS No. | 72741-87-8 |
存储
store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
Ethanol: 9.0 mg/mL (52.0 mM ),Need ultrasonic and warming
DMSO: 9.0 mg/mL (52.0 mM ),Need ultrasonic and warming
H2O: 3.2 mg/mL (18.5 mM ),ultrasonic and warming and heat to 60°C
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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