Dolastatin 10

Dolastatin 10 is a potent antimitotic peptide that inhibits tubulin polymerization.

Dolastatin 10 is a unique pentapeptide that isolated from the sea hare?Dolabella auricularia. These in vitro data are quite comparable to those of Dolastatin 10 and Auristatin PE, each of which has GI50?values of 10?5-10?6?μg/mL (10?2-10?3?nM) against a similar minipanel of human cell lines[1]. The antibody-drug conjugate (ADC) comprises the anti-CD30 monoclonal antibody cAC10 conjugated to the cytotoxic agent monomethyl auristatin E (MMAE), a synthetic analog of the tubulin polymerization inhibitor Dolastatin 10[2].

110417-88-4

C42H68N6O6S

785.09

尾海兔素10;DLS 10;NSC 376128;Dolastatin 10

[1]Pitot HC, et al. Phase I trial of dolastatin-10 (NSC 376128) in patients with advanced solid tumors. Clin Cancer Res. 1999 Mar;5(3):525-31.

DMSO:100 mg/mL (127.37 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years