Substance P (1-7) 2TFA(68060-49-1(free base))
作者：齐岳
发布时间：2023-06-26
09:06:25
点击数：
产品名称：Substance P (1-7) 2TFA(68060-49-1(free base))
产品描述：
Substance P (1-7) 2TFA(68060-49-1(free base)) is the major bioactive metabolite formed after proteolytic degradation of the tachykinin substance P (SP),with anti-inflammatory, anti-nociceptive and anti-hyperalgesic effects
Substance P 1-7, SP(1-7), which is the main SP fragment in rat CNS, was injected intranigrally. SP(1-7) was found to act as a very potent antagonist against the SP-induced responses and was formed locally in the nigra after SP injection. It is proposed that SP(1-7) is an endogenous modulator of SP actions. Generation of peptide fragments, which retain receptor affinity but not efficacy, may be a general mechanism for autoregulation in peptidergic systems[1].
T7675
C45H67F6N13O14
1128.08
Substance P (1-7) 2TFA(68060-49-1(free base))
[1]Herrera-Marschitz M , Terenius L , Sakurada T , et al. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain[J]. Brain Research, 1990, 521(1-2):316-320.[2]Skogh A , Lesniak A , Gaugaz F Z , et al. Impact of N -methylation of the substance P 1–7 amide on anti-allodynic effect in mice after peripheral administration[J]. European Journal of Pharmaceutical Sciences, 2017, 109.
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
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