Desmopressin acetate (16679-58-6 free base)

Desmopressin is the synthetic analog of the antidiuretic hormone arginine vasopressin. Vasopressin Receptor The antidiuretic properties of desmopressin have led to its use in polyuric conditions including primary nocturnal enuresis, nocturia, and diabetes insipidus. Desmopressin works by limiting the amount of water that is eliminated in the urine. Desmopressin binds to V2 receptors in renal collecting ducts, increasing water reabsorption. It also stimulates the release of von Willebrand factor from endothelial cells by acting on the V2 receptor.

62288-83-9

C48H68N14O14S2

1129.28

DDAVP;醋酸去氨加压素;Desmopressin acetate;Desmopressin acetate (16679-58-6 free base)

[1]Tsukamoto I. Recent patenting activities in the discovery and development of vasopressin V2 receptor agonists. Expert Opin Ther Pat. 2012 Jun;22(6):579-86.[2]Kaufmann JE, et al. Desmopressin (DDAVP) induces NO production in human endothelial cells via V2 receptor- and cAMP-mediated signaling. J Thromb Haemost. 2003 Apr;1(4):821-8.

[1]Wang S Q, Li C L, Xu J Q, et al. The Effect of Endolymphatic Hydrops and Mannitol Dehydration Treatment on Guinea Pigs. Frontiers in Cellular Neuroscience. 2022, 16

H2O:50 mg/mL
DMSO:10 mM
Ethanol:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years