HYPOCRELLIN B
作者：齐岳
发布时间：2023-09-06
08:59:44
点击数：
产品名称：HYPOCRELLIN B
产品描述：
| 结构类型 | 天然产物 > 醌类 |
| 产品描述 | HYPOCRELLIN B are photosensitive pigments isolated from Hypocrella bambusae Sacc. Hypocrellin B causes DNA strand breakage, induces apoptosis in ovarian cancer cells, and inhibits proliferation of Staphylococcus by increasing ROS levels, and damaging cell walls. |
| 体外活性 | Photodynamic therapy with hypocrellin B remarkably induced apoptosis and inhibited adhesion and migration of cancer cells in vitro. |
| 细胞实验 | Human ovarian cancer HO-8910 cell as a cancer model cell was incubated with hypocrellin B at a concentration of 2.5 μM for 5 h and irradiated by light from a light-emitting diodes (LED) source. Cell apoptosis was analyzed by flow cytometry with annexin V/propidium iodide (PI) staining and nuclear staining 6 h after hypocrellin B photoirradiation. Cell adhesion was assessed using the 3-(4, 5-dimthylthiazol-2-yl)-2, 5 diphenyl-tetrazolium bromide (MTT) assay 4 h after photodynamic treatment. Cell migration was measured 48 h after photodynamic treatment. |
| 分子量 | 528.51 |
| 分子式 | C30H24O9 |
| CAS No. | 123940-54-5 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: insoluble
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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