Cirsilineol
作者：齐岳
发布时间：2023-09-05
08:50:42
点击数：
产品名称：Cirsilineol
产品描述：
| 结构类型 | 天然产物 > 类黄酮 |
| 产品描述 | Cirsilineol is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selectively induces apoptosis via the mitochondrial pathway. |
| 体外活性 | Cirsilineol (0.1, 1, 10 μM) dose-dependently inhibits single mixed lymphocyte reaction and the proliferation of Concanava A-induced T-cells in Splenocytes. Cirsilineol (1, 5, 10 μM) inhibits IFN-γ-induced Tyr701 phosphorylation of STAT1 and the activation of JAK2 in Splenic CD4+ T cells[3]. |
| 体内活性 | In female C57BL/6, BALB/c, and DO11.10 transgenic mice with TNBS, Cirsilineol (3-30 mg/kg) reduces inflammatory infiltration, restores the destructive mucosal architecture, and remisses edema thus improving the effects on the body weights and survival rate of mice. Cirsilineol ameliorates TNBS-induced Th1-mediated colitis by inhibiting IFN-γ/STAT1/T-bet signaling in CD4+ T cells[1]. |
| 别名 | Fastigenin, SPM 927, Eupatrin |
| 分子量 | 344.32 |
| 分子式 | C18H16O7 |
| CAS No. | 41365-32-6 |
存储
store at low temperture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: Soluble
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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