Ecdysone
作者：齐岳
发布时间：2023-09-05
08:50:39
点击数：
产品名称：Ecdysone
产品描述：
| 植物来源 | 天然产物 > 鸭跖草科 > 蓝耳草属 |
| 结构类型 | 天然产物 > 其他 |
| 产品描述 | Ecdysone is a major steroid hormone in insects and herbs. Ecdysone triggers mineralocorticoid receptor activation and induces cellular apoptosis. Ecdysone signaling through Ecdysone receptor isoform B1 is required cell autonomously for the muscle death. |
| 体外活性 | Ecdysone (10, 100 nM) induced the expression of a-smooth muscle actin (SMA). Ecdysone elevated the expression of cleaved caspase 3 in a dose dependent manner. Ecdysone (10, 100 nM) suppressed cell motility and scratch wound closure to a comparable extent[4]. Ecdysone (100 nM) induced a branched spindle mesenchymal-like cell shape. Ecdysone (100 nM) caused renal tubular inner medullary collecting duct cells apoptosis[4]. |
| 体内活性 | In male C57BL/6 mice, Ecdysone (6 μg/g/day; s.c.) significantly impaired renal function, and BUN levels were statistically significantly increased, amplifying the renal expression of α-SMA. Ecdysone also displayed MR-dependent nephrotic effects[4]. |
| 分子量 | 464.63 |
| 分子式 | C27H44O6 |
| CAS No. | 3604-87-3 |
存储
| Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 60 mg/ml (129.14 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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