Chelidonic acid
作者：齐岳
发布时间：2023-08-29
13:40:53
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产品名称：Chelidonic acid
产品描述：
| 植物来源 | 天然产物 > 罂粟科 > 白屈菜属 |
| 结构类型 | 天然产物 > 其他 |
| 产品描述 | Chelidonic acid is a component of Chelidonium majus L., used as a mild analgesic, an antimicrobial, an acentral nervous system sedative. Chelidonic acid also shows anti-inflammatory activity. |
| 靶点活性 | Glutamate decarboxylase:1.2 μM (Ki) |
| 体内活性 | Chelidonic acid (0.2, 2 mg/kg p.o.) attenuates allergic reaction induced by ovalbumin in mice[3]. Chelidonic acid may attenuate allergic reactions by inhibiting caspase-1 activity. |
| 动物实验 | female BALB/c mice was Maintained 6-week-old under pathogen-free conditions.?Sensitized mice on days 1, 5, and 14 by intraperitoneal ?injection of 100 μg OVA emulsified in 20 mg aluminum hydroxide and we challenged mice with 1.5 mg OVA.?Chelidonic acid was administrated orally before intranasal .?OVA challenge for 10 days.?Nasal symptoms were evaluated by counting the number of nasal rubs that occurred in the 10 min after OVA. provocation at 10 days after challenge. |
| 别名 | γ-Pyrone-2,6-dicarboxylic acid, 白屈菜酸, Jerva acid, Jervaic acid |
| 分子量 | 184.103 |
| 分子式 | C7H4O6 |
| CAS No. | 99-32-1 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 4 mg/mL (21.72 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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