Phenoxodiol
作者：齐岳
发布时间：2023-08-28
09:04:39
点击数：
产品名称：Phenoxodiol
产品描述：
| 产品描述 | Phenoxodiol activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis(XIAP), disrupts FLICE inhibitory protein(FLIP) expression, and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner. Phenoxodiol also inhibits DNA topoisomerase II. |
| 体外活性 | Phenoxodiol, at concentrations >or=1 microg/ml (4 microM), inhibited proliferation and reduced the viability of healthy donor-derived PBMC. In contrast, lower Phenoxodiol concentrations (0.05-0.5 microg/ml) augmented, upon 3-day incubation, peripheral blood mononuclear cells cytotoxicity. Experiments with purified CD56(+) lymphocytes revealed that Phenoxodiol enhanced the lytic function of natural killer cells by directly stimulating this lymphocytic subpopulation[3]. |
| 体内活性 | Balb/C mice administered low-dose Phenoxodiol exhibited significantly reduced tumour growth rates and prolonged survival (in 40% of the animals) in a colon cancer model[3]. |
| 别名 | Idronoxil, 脱氢雌马酚, Haginin E, Dehydroequol |
| 分子量 | 240.25 |
| 分子式 | C15H12O3 |
| CAS No. | 81267-65-4 |
存储
Powder: -20°C for 3 years | In solvent: -80°C for 2 years
溶解度
DMSO: 50 mg/mL (208.12 mM)
( < 1 mg/mL refers to the product slightly soluble or insoluble )
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